Levodopa‐dyskinesia incidence by age of Parkinson's disease onset
Identifieur interne : 003864 ( Main/Exploration ); précédent : 003863; suivant : 003865Levodopa‐dyskinesia incidence by age of Parkinson's disease onset
Auteurs : Neeraj Kumar [États-Unis] ; Jay A. Van Gerpen [États-Unis] ; James H. Bower [États-Unis] ; J. Eric Ahlskog [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-03.
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Aged, 80 and over, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Cohort Studies, Dyskinesia, Drug-Induced (etiology), Female, Humans, Incidence, Levodopa (adverse effects), Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Parkinson's disease, Retrospective Studies, age, levodopa‐induced dyskinesias, population.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- drug therapy : Parkinson Disease.
- epidemiology : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- Adult, Age of Onset, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Incidence, Male, Middle Aged, Retrospective Studies.
Abstract
We assessed the 5‐year risk of levodopa‐induced dyskinesias by age of Parkinson's disease (PD) onset in a population‐based cohort. The medical records linkage system of the Rochester Epidemiology project was used to identify residents of Olmsted County, Minnesota, with incident PD for the period 1976 through 1990. In this population‐based study, the 5‐year dyskinesia incidence declined with age. With PD onset after 70 years of age, the incidence was 16%. With onset from 40 to 59 years of age, the incidence was higher at 50%. These incidence data may overestimate the functional importance, because patients with minimal or reversible dyskinesias were counted. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20360
Affiliations:
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Le document en format XML
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<term>Antiparkinson Agents (therapeutic use)</term>
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<term>Humans</term>
<term>Incidence</term>
<term>Levodopa (adverse effects)</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson's disease</term>
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<term>age</term>
<term>levodopa‐induced dyskinesias</term>
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<front><div type="abstract" xml:lang="en">We assessed the 5‐year risk of levodopa‐induced dyskinesias by age of Parkinson's disease (PD) onset in a population‐based cohort. The medical records linkage system of the Rochester Epidemiology project was used to identify residents of Olmsted County, Minnesota, with incident PD for the period 1976 through 1990. In this population‐based study, the 5‐year dyskinesia incidence declined with age. With PD onset after 70 years of age, the incidence was 16%. With onset from 40 to 59 years of age, the incidence was higher at 50%. These incidence data may overestimate the functional importance, because patients with minimal or reversible dyskinesias were counted. © 2004 Movement Disorder Society</div>
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<name sortKey="Van Gerpen, Jay A" sort="Van Gerpen, Jay A" uniqKey="Van Gerpen J" first="Jay A." last="Van Gerpen">Jay A. Van Gerpen</name>
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